By N. Kukreja
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2000;19(4):453-473. Cook NR. Statistical evaluation of prognostic versus diagnostic models: beyond the ROC curve. Clin Chem. 2008;54(1):17-23. Granton J, Cheng D. Risk stratification models for cardiac surgery. Semin Cardiothorac Vasc Anesth. 2008;12(3):167-174. Hamburger JN, Walsh SJ, Khurana R, Ding L, Gao M, Humphries KH, Carere R, Fung AY, Mildenberger RR, Simkus GJ, Webb JG, Buller CE. Percutaneous coronary intervention and 30-day mortality: the British Columbia PCI risk score. Catheter Cardiovasc Interv.
5 Local mechanical irritation of the vessel can occur from fractured stent struts, which may result in inflammation and neointimal hyperplasia. 13 Exposure of a free metal strut protruding into the vessel lumen could trigger platelet activation and resultant stent thrombosis. Acute myocardial infarction and sudden death can develop from fracturerelated stent thrombosis. 5 Diagnosis and treatment Usually stent fracture can be diagnosed by conventional fluoroscopy or follow-up coronary angiography.
It is a prospective evaluation of the original model, but it may take considerable time to accrue an adequate number of events in the second dataset. External – evaluation of geographically separate cohorts External validation addresses the generalizability of the statistical model by application to a different population from that used to derive the model. It can be performed retrospectively making it attractive for widespread application and can help address issues related to sample selection.
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