By Jean-Maurice Vergnaud

Numerical research of topic move is a space that pharmacists locate tough, yet that is a strategy often utilized in getting ready managed drug unlock and oral dosage varieties. This e-book offers transparent and simple info allowing the reader to hold out numerical research of subject move - an essential processs while taking a look at the formula of oral dosage kinds with managed drug unencumber. The drug is dispersed in a polymeric matrix both biodegradable or now not, the foundation of that's the move of the liquid and the drug via dosage shape. details in this diffusion is located both via mathematical therapy whilst the matter is straightforward, or via numerical research for extra complicated difficulties. Professor Vergnaud demonstrates and clarifies those, modelling the method of drug supply by utilizing numerical research and computerization. A simulation of the method is supplied, including a decision of the consequences of all parameters, and the writer makes use of either mathematical and numerical types to foretell the education of latest dosage varieties capable of fulfil particular stipulations.

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Extra resources for Controlled Drug Release Of Oral Dosage Forms

Example text

1 of diffusion in INTRODUCTION A plane sheetis a medium bounded by two parallel planes of infinite dimensions. In this case,a one-dimensionaldiffusion of substanceis thus considered. In fact, the plane sheetis so thin with respectto the other two dimensionsthat all the substance diffuses along the axis perpendicular to the plane faces and the amount transferredthrough the edgesis negligible. Various casesare of interest, depending on the value of the coefficient of matter transferon the substanceand on the volume of solution in which the plane sheetis placed.

Initial and boundary conditions. 2 NON-STEADY STATE WITH A HIGH COEFFICIENT MATTER TRANSFER ON THE SURFACE AND AN INFINITE VOLUME OF THE SURROUNDING OF This is the casewhere the volume of the surrounding atmosphereis so high with respectto the volume of the sheetthat it can be consideredas infinite. 4. The concentration on the surfacesof the sheetcan thus be considered as constant. They are equal to the concentration of the surrounding atmosphere,when the partition factor is 1 and to KC,,, when there is a partition factor K.

2 sheet surfaces The condition on the surface expressesthat the rate at which the substanceleaves the sheetis constantly equal to the rate at which the substanceis brought to the surfaceby internal diffusion. This concentrationis written C, as it is also the value obtainedfor C, at infinite time. 8452 Sec. 54) M;Mt = 2 00 n=l 2M2 exp p;(~~+ M2+ Ml Of course, depending on the relative values of the concentrations C, and C,, the substanceentersor leavesthe sheet. i-i5 as a function of L, ca with the thickness2 L of the sheet Fig.

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