By Cathy H. Wu, Paul P. Wang, Jason T. L. Wang
This learn includes articles written via specialists on quite a lot of subject matters which are linked to the research and administration of organic details on the molecular point. It includes chapters on RNA and protein constitution research, DNA computing, series mapping, genome comparability, gene expression info mining, metabolic community modelling, and phyloinformatics. the $64000 paintings of a few consultant researchers in bioinformatics is introduced jointly. the subject is handled intensive and is expounded to, the place acceptable, different rising applied sciences akin to info mining and visualization. The objective of the paintings is to introduce readers to the primary concepts of bioinformatics within the wish that they're going to construct on them to make new discoveries in their personal
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Extra resources for Computational biology and genome informatics
Containing multiple copies of whole genes - 'tandem repeats'. Made of DNA that is not repeated. The highly repetitive DNA is found mainly in regions of heterochromatin, such as around and in the centromere (see chapter 5). (b) Multiple copies of cistrons - tandem repeats The moderately repetitive DNA is thought to consist mainly of entire genes that have been duplicated lengthwise along the chromosome 'tandem duplication'. So far relatively few genes have been found to be duplicated precisely in this way, though there are long sequences of homology in related genes which may indicate that they have evolved by such a process, as for example the haemoglobins.
In other words the true environment of the gene is both the rest of the genome and the environment external to the cell or organism. It is the gene complex that confers advantages or disadvantages for natural selection. The force of selection on any one gene will be much affected by the extent to which the gene concerned interacts with the other genes of the genome, and what the effects of those interactions are. It should also be borne in mind that any gene may have several alternative forms in a population, these being called alleles.
Palaeogenes These are genes that have been present in a given genome for a very long time. Dr E. B. Ford and Dr McWhirter have suggested that strong evidence for a gene being ancient can be taken from the number of modifiers of the gene in the genome which affect its expression or degree of dominance. This is rather the same argument as that applied to dating hedges by the numbers of species present in them. The strength of the effect of the rest of the genome on the dominance of the gene for melanism in the peppered moth Biston betularia was tested by Dr Kettlewell.
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