By Johanna L'age-Stehr

International experts in Microbiology, Infectious illnesses, inner medication, Cardiology Immunology, Pneumonolgy, Neurology and Epidemiology accumulated to this workshop to debate and improve interdisciplinary wisdom at the attainable etiological position of Chlamydia pneumoniae, a frequent human breathing an infection, within the pathogenesis of power inflammatory illnesses with significant public healthiness impression akin to: - atherosclerosis, - heart problems, - grownup onset bronchial asthma bronchiale, - continual obstructive pulmonary diseases,- reactive arthritis,- Morbus Alzheimer and - a number of Sclerosis. present deficits and targets in standardisation of diagnostic instruments, easy and utilized study, layout of epidemiological and tracking of remedy reviews have been pointed out. a distinct function of this e-book is the great choice of state-of-the-art assessment articles within the a number of fields with many references and the enclosure of the controverse discussions to every article which gives the reader with a lifely photo at the position of Chlamydia pneumoniae in persistent diseases.

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Extra info for Chlamydia pneumoniae and Chronic Diseases: Proceedings of the State-of-the-Art Workshop held at the Robert Koch-Institut Berlin on 19 and 20 March 1999

Example text

However, the problems with cultural recovery of C. pneumoniae still result in a distinctly decreased sensitivity of even the most current culture procedures in comparison to PCR. Furthermore, presence of DNA in the absence of cultural recovery could be consistent with temporarily non-replicating bacteria causing persistent disease. Clearly, cultural attempts have been necessary to demonstrate the presence of viable bacteria within lesions and to recover vascular strains for further characterization, but laborious cell culture protocols involving eight and more subcultures are not the diagnostic assay of choice for identifying infected vessels.

Pneumoniae is characterized by an extraordinarily high seroprevalence: seroepidemiological surveys indicate virtually everybody to be infected with the organism at least once during lifetime and reinfections to be common [12]. Nevertheless, it has been extremely difficult to recover viable isolates from the site of infection. In fact, this difficulty in adapting primary isolates to the artificial conditions of cell culture has been the reason why this extremely frequent bacterial pathogen has not been identified earlier than 1986 [8].

I think that this is an important feature, as Dr. Byrne mentioned in his talk as well. 4 Molecular biology and serodiagnostics of Chlamydia pneumoniae - potential way to a vaccine G. S. Madsen, T. Boesen, K. HjernfJ, L. Daugaard, K. Knudsen, P. Mygind, S. Birkelund Introduction In Chlamydia, the obligate intracellular human pathogen with a unique biphasic life cycle, surface structures are of importance for induction of uptake in host cells, for protection of Chlamydiae at the extracellular stage, and as immunogens to which the host's humoral immune response is directed.

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