By Jonathan Gillard, Dr Martin Graves, Thomas Hatsukami, Chun Yuan

Stroke is an enormous explanation for morbidity and mortality, with carotid affliction representing a big contributory hazard issue. This e-book deals complete insurance of the pathogenesis and administration of carotid illness with particular specialise in the position imaging has to play within the early popularity of symptomatic and asymptomatic illness in addition to the therapy of the built situation. Technological advances in imaging modalities now enable unique research of the illness development, the prediction of serious occasions resulting in a stroke, in addition to the id of the best surgical or different interventional remedies. This booklet may be learn via neurologists, cardiologists, vascular surgeons, neurosurgeons and radiologists thinking about the care of sufferers with carotid sickness, and likewise by means of researchers inquisitive about the improvement of latest healing options and drugs.Stroke is a massive explanation for morbidity and mortality, with carotid illness representing an immense contributory hazard issue. This ebook bargains entire assurance of the pathogenesis and administration of carotid affliction with particular specialise in the function imaging has to play within the early acceptance of symptomatic and asymptomatic ailment in addition to the therapy of the built . It discusses the technological advances in imaging modalities which now let specific research of the affliction development, the prediction of serious occasions resulting in a stroke, in addition to the id of the simplest surgical or different interventional remedies. hugely illustrated all through with top specialist members, this publication might be learn through neurologists, cardiologists, vascular surgeons, neurosurgeons and radiologists taken with the care of sufferers with carotid disorder, and likewise through researchers thinking about the advance of latest healing thoughts and medicine.

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Zhao et al. analyzed carotid endarterectomy specimens from patients treated for 10 years with lipid-lowering agents in the Familial Atherosclerosis Treatment Study (FATS). , 2001). , 1997). Hypercholesterolemia also correlates with the number of thin-cap atheromas. Burke et al. also 15 16 R. Virmani et al. demonstrated that CRP is significantly elevated in patients dying suddenly with severe coronary disease, both with and without coronary thrombosis, and correlates with plaque burden. , 2002).

Vulnerable plaque is a concept well accepted in the coronary circulation but not so well established in the carotid plaque. In studies carried out in the coronary circulation it has been shown that plaque ruptures often occur at low degrees of luminal narrowing and that percent stenosis is a poor predictor of plaque rupture. Ambrose et al. , 1988). , 1995). Wasserman et al. 8). , 2005). , 2001). 9). 6 Calcification and bone formation in atherosclerotic plaques. (A) is a section of a carotid plaque showing plaque hemorrhage within a necrotic core, note presence of calcification at the periphery of the necrotic core close to the outer wall, which is highlighted in the insert.

Burke et al. also 15 16 R. Virmani et al. demonstrated that CRP is significantly elevated in patients dying suddenly with severe coronary disease, both with and without coronary thrombosis, and correlates with plaque burden. , 2002). , 2000). 8%) patients were reoperated on for recurrent carotid stenosis occurring 3 to 194 months (mean 42 months) after the initial procedure. Of these patients, approximately half were symptomatic with neurologic symptoms and half were asymptomatic. 0007). In recurrent disease, the myointimal hyperplasia consisted of smooth muscle cells in a proteoglycan matrix interspersed with fibrin; the collagen and elastin representing organization of the thrombus is sparse.

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