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This new quantity includes severe new chapters on Combinational Chemistry and a number of Parallel Synthesis, excessive Throughput Pharmacology, and Retrometabolism-Based Drug layout and focusing on.
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Extra resources for Burger's Medicinal Chemistry and Drug Discovery, Vol. 2: Drug Discovery and Drug Development
Gel filtration is also helpful in sorting out a binding component from a mixture library containing analogs with little affmity for the pharmacological target. Because of the impact of these newer methods, today one rarely sees a separatory funnel in a combichem laboratory. This chemistry is also comparatively "green" in that solvent needs can be greatly reduced and disposal of unwanted materials is simplified. 2 Synthetic Success and Product Purity Only a relatively few census reports assessing the success rate of combinatorial library con- struction are available (1481, but the consensus is that 85% success is fine.
The full range of technologies and approaches that have been brought to bear on this complex activity will also be highlighted. - 2 HISTORY OF LEAD DISCOVERY AND SCREENING Serendipity has been the key to the pharmaceutical industry's success over many decades. 2 History of Lead Discovery and Screening The emergence of this "accidental" approach to drug discovery has its origins in early history with traditional natural herbal remedies that were passed from generation to generation in local communities or tribes.
Yiotakis, A. Michaud, S. , Proc. Natl. Acad. Sci. USA, 96,4330 (1999). 106. J . Jiracek, A. Yiotakis, B. Vincent, B. Checler, and V . Dive, J. Biol. , 271, 19606 (1996). 107. M. Bastos, N. J. Maeji, and R. H. Abeles, Proc. Natl. Acad. Sci. USA, 92,6738 (1995). 108. J. M . Salvino, R. Mathew, T . Kiesow, R. Narensingh, H. J. , Biorg. Med. Chem. , 10, 1637 (2000). 109. S. M. Dankwaardt, R. J. Billedeau, L. K. Lawley, S. C. Abbot, R. L. , Biorg. Med. Chem. , 10, 2513 (2000). 110. T. A. Rano, T . Timkey, E.
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