By M. Eric Gershwin, Timothy E. Albertson

This fourth version of Gershwin & Albertson's vintage asthma: ideas of prognosis and remedy has been greatly up-to-date and multiplied to incorporate, from a number of disciplines, the most recent diagnostic recommendations and advancements within the scientific evaluation and remedy of bronchial asthma. as well as its accomplished assurance and readable presentation, this drastically extended version describes the easiest functional methods to the analysis and remedy of bronchial asthma in either adults and youngsters; studies the consequences of being pregnant, workout, and drug abuse on bronchial asthma; information bronchial asthma pathophysiology; and discusses the scientific, criminal, and social facets of treating the bronchial asthma sufferer. state-of-the-art and hugely functional, this fourth variation of asthma: rules of analysis and therapy is an imperative instrument for all basic care companies, allergists, and pulmonologists treating sufferers with bronchial asthma at the present time.

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The effect of maternal smoking during pregnancy on early infant lung function. Am Rev Respir Dis 1992; 145: 1129–1135. 145. Hoo AF, Henschen M, Dezateux C, Costeloe K, Stocks J. Respiratory function among preterm infants whose mothers smoked during pregnancy. Am J Respir Crit Care Med 1998; 158: 700–705. Mediators and Mechanisms 29 2 Pathogenesis of Asthma Mediators and Mechanisms MAURICE E. HAMILTON, MD AND M. ERIC GERSHWIN, MD Contents Key Points Introduction Mast Cells Eosinophils Basophils Neutrophils Mononuclear Phagocytes Lymphocytes Cytokines Key Points • Asthma is characterized by reversible obstruction and hyperreactivity of the airways associated with an inflammatory infiltration by lymphocytes, macrophages, and eosinophils which may induce airway remodeling and permanent lung damage.

Smedje G, Norback D, Edling C. Asthma among secondary schoolchildren in relation to the school environment. Clin Exp Allergy 1997; 27: 1270–1278. 106. Black PN, Sharpe S. Dietary fat and asthma: is there a connection? Eur Respir J 1997; 10: 6–12. 107. Hodge L, Peat JK, Salome C. Increased consumption of polyunsaturated oils may be a cause of increased prevalence of childhood asthma. Aust N Z J Med 1994; 24: 727. 108. Chang CC, Phinney SD, Halpern GM, Gershwin ME. Asthma mortality: another opinion—is it a matter of life and.

Association of radiologically ascertained pneumonia before age 3 yr with asthmalike symptoms and pulmonary function during childhood. Am J Respir Crit Care Med 1999; 159: 1891–1897. 92. Hahn DL, Dodge RW, Golubjatnikov R. Association of Chlamydia pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis, and adult onset asthma. JAMA 1991; 266: 225–230. 93. Hahn DL, McDonald R. Can acute Chlamydia pneumoniae respiratory tract infection initiate chronic asthma? Ann Allergy Asthma Immunol 1998; 81: 339–344.

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