By Tao Jiang, Ueng-Cheng Yang, Yi-Ping Phoebe Chen, Limsoon Wong

High-throughput sequencing and practical genomics applied sciences have given us a draft human genome series and feature enabled large-scale genotyping and gene expression profiling of human populations. Databases containing huge numbers of sequences, polymorphisms, and gene expression profiles of standard and diseased tissues in several scientific states are swiftly being generated for human and version organisms. Bioinformatics is therefore swiftly growing to be in value within the annotation of genomic sequences, within the realizing of the interaction among genes and proteins, within the research of the genetic variability of species, and so forth. This lawsuits comprises an up to date alternate of data, principles, and ideas to conceptual and useful problems with bioinformatics, by way of researchers, pros, and business practitioners on the 4th Asia-Pacific Bioinformatics convention held in Taipei in February 2006.

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Extra info for Bioinformatics: Proceedings of the 4th Asia-Pacific Conference, Taipei, Taiwan 13-16 February, 2006 (Series on Advances in Bioinformatics and Computational Biology)

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Frey and I. Lefkovits. Proteome, transcriptome and genome: top down or bottom up analysis. Biomol. , 18:207-212,2001. 2. J. C. Von Brevern, A. Horlein, A. Fischer, A. Schneider and A. Bach. 3. 4. 5. 6. 7. 8. 9. 10. 11. Yellow pages to the transcriptome. Pharmucogenomics, 3:791-807,2002. S. Motaki, K. Ayako, Y. S. Kazuko and S. Kazuo. Molecular response to drought, salinity and frost: common and different paths for plant protection. Cur. Opn. , 14:194-199,2003. T. S. Hughes, B. Abou-Khalil, P. J.

References 1. J. R. Kettman, J. R. Frey and I. Lefkovits. Proteome, transcriptome and genome: top down or bottom up analysis. Biomol. , 18:207-212,2001. 2. J. C. Von Brevern, A. Horlein, A. Fischer, A. Schneider and A. Bach. 3. 4. 5. 6. 7. 8. 9. 10. 11. Yellow pages to the transcriptome. Pharmucogenomics, 3:791-807,2002. S. Motaki, K. Ayako, Y. S. Kazuko and S. Kazuo. Molecular response to drought, salinity and frost: common and different paths for plant protection. Cur. Opn. , 14:194-199,2003.

Figure. 3. Gene interaction diagram discovered (12 known regulatory relationships involved). Solid lines correspond to activation relationships and broken lines correspond to inhibition relationships. 4 Conclusions In this paper, we have presented a novel fuzzy logic-based approach for the inference of GRNs. The proposed algorithm is able to distinguish between relevant and irrelevant expression data in predicting the expression patterns of predicted genes without the need for additional feature selection procedures.

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