By Matthew N. Davies, Darren R. Flower (auth.), Darren D.R. Flower, Matthew Davies, Shoba Ranganathan (eds.)
The box of Immunomics has built in the post-genomic period as a reaction to the large quantity of organic and immunological information now on hand to researchers. Immunomics crosses the disciplines of immunology, genomics, proteomics and computational biology and deal with a few primary difficulties in organic and scientific examine. This booklet covers many of the wealthy assets of immunological facts which are at the moment on hand and describes some of the bioinformatics ideas which have been applied to help our realizing of the immune approach. It additionally describes the character of the self/non-self contrast that types the foundation of immunological idea and the way computational modeling may help to elucidate our knowing of the way the immune method works.
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Extra resources for Bioinformatics for Immunomics
De/oister/). Consequently ESTDAB now provides access to many more cell lines of melanoma origin than are available from other non-specialist cell banks. The IPD-ESTDAB section of the website provides an online search facility for cells stored in this cell bank. This enables investigators to identify cells possessing specific parameters important for studies of immunity, immunogenetics, gene expression, metastasis, response to chemotherapy and other tumour biological experimentation. The search tool allows for searches based on a single parameter, or clusters of parameters on over 250 different markers for each cell.
For some species or related species groups, such as the bovines, non-human primates (NHP) and dogs, there have been efforts to use a standardised nomenclature system and establish comprehensive datasets (Kennedy et al. 1999; Klein et al. 1990; Stear et al. 1990). The availability of these datasets for use by other groups has often been limited by a lack of informatics resources available to the researchers compiling the datasets. The aim of the IPD-MHC database is to address this issue and provide a centralised database which will facilitate the comparative analysis of these sequences which are highly conserved between different closely related species (Parham 1999).
IPD-KIR The Killer-cell Immunoglobulin-like Receptors (KIR) are members of the immunoglobulin super family (IgSF) formerly called Killer-cell Inhibitory Receptors. KIRs have been shown to be highly polymorphic both at the allelic and haplotypic levels (Garcia et al. 2003). They are composed of two or three Ig-domains, a transmembrane region and cytoplasmic tail, which can in turn be short (activatory) or long (inhibitory). The Leukocyte Receptor Complex (LRC), which encodes KIR genes, has been shown to be polymorphic, polygenic and complex in a manner similar to the MHC, because of the complexity in the KIR region and KIR sequences a KIR Nomenclature Committee was established in 2002, to undertake the naming of KIR allele sequences.
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