By Jonathan Pevsner

The bestselling creation to bioinformatics and sensible genomics—now in an up to date variation

broadly obtained in its earlier variation, Bioinformatics and useful Genomics bargains the main broad-based advent to this explosive new self-discipline. Now in a completely up to date and multiplied Second Edition, it remains to be the go-to resource for college students and pros excited about biomedical learn.

This variation presents up to date assurance of the fields of bioinformatics and genomics. good points new to this version contain:

  • Several essentially vital proteins, equivalent to globins, histones, insulin, and albumins, are incorporated to raised convey find out how to observe bioinformatics instruments to easy organic questions.
  • A thoroughly up-to-date companion net site, with a purpose to be up-to-date as new details turns into on hand - stopover at www.wiley.com/go/pevsnerbioinformatics
  • Descriptions of genome sequencing tasks spanning the tree of existence.
  • A better concentrate on how bioinformatics instruments are used to appreciate human ailment.

The e-book is complemented by way of lavish illustrations and greater than 500 figures and tables—fifty of that are completely new to this version. each one bankruptcy encompasses a challenge Set, Pitfalls, packing containers explaining key recommendations and mathematics/statistics ideas, precis, instructed examining, and a listing of freely on hand software program. Readers might stopover at a comparable web content for supplemental details at www.wiley.com/go/pevsnerbioinformatics.

Bioinformatics and useful Genomics, moment Edition serves as an exceptional single-source textbook for complex undergraduate and starting graduate-level classes within the organic sciences and machine sciences. it's also an necessary source for biologists in a large number of disciplines who use the instruments of bioinformatics and genomics to review specific study difficulties; bioinformaticists and laptop scientists who enhance computing device algorithms and databases; and scientific researchers and clinicians who are looking to comprehend the genomic foundation of viral, bacterial, parasitic, or different ailments.

Praise for the 1st edition:

"...ideal either for biologists who are looking to grasp the appliance of bioinformatics to real-world difficulties and for desktop scientists who have to comprehend the organic questions that inspire algorithms." Quarterly evaluation of Biology

"… a great textbook for graduate scholars and top point undergraduate students." Annals of Biomedical Engineering

"…highly urged for educational and clinical libraries, and for researchers as an creation and reference…" E-StreamsContent:
Chapter 1 advent (pages 3–11):
Chapter 2 entry to series info and Literature details (pages 12–45):
Chapter three Pairwise series Alignment (pages 46–98):
Chapter four simple neighborhood Alignment seek instrument (BLAST) (pages 100–138):
Chapter five complex Database looking out (pages 140–177):
Chapter 6 a number of series Alignment (pages 178–212):
Chapter 7 Molecular Phylogeny and Evolution (pages 214–275):
Chapter eight Bioinformatic techniques to Ribonucleic Acid (RNA) (pages 279–328):
Chapter nine Gene Expression: Microarray facts research (pages 330–376):
Chapter 10 Protein research and Proteomics (pages 378–418):
Chapter eleven Protein constitution (pages 420–459):
Chapter 12 useful Genomics (pages 460–514):
Chapter thirteen accomplished Genomes (pages 517–565):
Chapter 14 accomplished Genomes: Viruses (pages 566–595):
Chapter 15 accomplished Genomes: micro organism and Archaea (pages 596–636):
Chapter sixteen The Eukaryotic Chromosome (pages 638–695):
Chapter 17 Eukaryotic Genomes: Fungi (pages 696–726):
Chapter 18 Eukaryotic Genomes: From Parasites to Primates (pages 728–788):
Chapter 19 Human Genome (pages 790–836):
Chapter 20 Human ailment (pages 838–889):

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Additional info for Bioinformatics and Functional Genomics, Second Edition

Example text

Slowly it is drawn together in a doughy mass, and beyond what is possible to be believed, tenacious, a remarkable sort of glue, and suited to many uses; and what is especially worthy of note, it cannot any longer be mixed with water. The other particles, which water carries away with itself, for some time float and render the water milky; but after a while they are carried to the bottom and sink; nor in any way do they adhere to each other; but like powder they return upward on the lightest contact.

The NCBI website offers a variety of other bioinformatics-related tools. We will gradually introduce the European Bioinformatics Institute (EBI) web server, which hosts a complementary DNA database (EMBL, the European Molecular Biology Laboratory database). We will also introduce the DNA Database of Japan (DDBJ). The research teams at GenBank, EMBL, and DDBJ share sequence data on a daily basis. Throughout this book we will highlight the key genome browser hosted by the University of California, Santa Cruz (UCSC).

From RNA we turn to consider proteins from the perspective of protein families, and the analysis of individual proteins (Chapter 10) and protein structure (Chapter 11). We conclude the middle part of the book with an overview of the rapidly developing field of functional genomics (Chapter 12). Since 1995, the genomes have been sequenced for several thousand viruses, prokaryotes (bacteria and archaea), and eukaryotes, such as fungi, animals, and plants. The third section of the book covers genome analysis (Chapters 13 to 20).

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