By Richard S. Larson
Contemporary advances in drug discovery were swift. The moment variation of Bioinformatics and Drug Discovery has been thoroughly up-to-date to incorporate issues that variety from new applied sciences in objective identity, genomic research, cheminformatics, protein research, and community or pathway research. every one bankruptcy presents a longer advent that describes the speculation and alertness of the know-how. within the moment a part of every one chapter, designated systems concerning using those applied sciences and software program were integrated. Written within the hugely winning tools in Molecular Biology™ sequence layout, the chapters comprise the type of targeted description and implementation suggestion that's the most important for buying optimum leads to the laboratory. Thorough and intuitive, Bioinformatics and Drug Discovery, moment variation seeks to help scientists within the extra learn of the speedily increasing box of drug discovery.
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Additional resources for Bioinformatics and Drug Discovery (Methods in Molecular Biology)
Splicing in mammalian cells from human, mouse, and rat (25). org). org) (26) and is also included in the AltAnalyze package. de) or via the Cytoscape plugin manager. 2. Statistical Exon Data Analysis Using AltAnalyze AltAnalyze supports the statistical analysis of raw Affymetrix CEL files containing exon expression results (27). It allows for a comparative analysis of pairs of biological groups, namely, the experimental group and the control group, to identify probesets that are differentially expressed between the two groups.
References 1. Kramer R, Cohen D (2004) Functional genomics to new drug targets. Nat Rev Drug Discov 3:965–972 2. Savoie CJ, Aburatani S, Watanabe S, Eguchi Y, Muta S, Imoto S, Miyano S, Kuhara S, Tashiro K (2003) Use of gene networks from full genome microarray libraries to identify functionally relevant drug-affected genes and gene regulation cascades. DNA Res 10:19–25 3. Dorsett Y, Tuschl T (2004) siRNAs: applications in functional genomics and potential as therapeutics. Nat Rev Drug Discov 3:318–329 4.
Coregulation analysis, determining whether the identified genes could be regulated by common transcription factors, brings the interpretation another step closer to understanding the molecular mechanism of disease, and is equally important in search for potential triggers of pathological processes as it is in considerations whether some differentially expressed genes should be considered as crucial for pathological changes or simple consequences of shared mechanism of transcriptional regulation.
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