By Edith Mathiowitz, Donald E. Chickering III, Claus-Michael Lehr

Evaluates the original provider features of bioadhesive polymers and their strength to augment localization of brought brokers, neighborhood bioavailability, and drug absorption and delivery! Written through over 50 foreign specialists and reflecting vast wisdom of either conventional bioadhesive innovations and novel scientific functions, Bioadhesive Drug supply structures discusses mechanical and chemical bonding, polymer-mucus interactions, the impression of floor strength in bioadhesion, polymer hydration, and mucus rheology analyzes biochemical homes of mucus and glycoproteins, mobilephone adhesion molecules, and mobile interplay with - and third-dimensional surfaces covers microbalances and magnetic strength transducers, atomic strength microscopy, direct measurements of molecular point adhesions, and strategies to degree cell-cell interactions examines bioadhesive companies, diffusion or penetration enhancers, and lectin-targeted autos describes vaginal, nasal, buccal, ocular, and transdermal drug supply stories bioadhesive interactions with the mucosal tissues of the attention and mouth, and people within the respiration, urinary, and gastrointestinal tracts explores problems with product improvement, medical checking out, and creation and extra! Amply referenced with over 1400 bibliographic citations, and illustrated with greater than three hundred drawings, pictures, tables, and exhibit equations, Bioadhesive Drug supply structures serves as a valid foundation for innovation in bioadhesive structures and a very good creation to the topic. This specified reference is perfect for pharmaceutical scientists and technologists chemical, polymer, and plastics engineers biochemists actual, floor, and colloid chemists biologists and upper-level undergraduate and graduate scholars in those disciplines.

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Extra resources for Bioadhesive Drug Delivery Systems Fundamentals, Novel Approaches, and Development

Example text

00©" varenicline (Chantix) In this section, only a small portion of marketed drugs are shown to illustrate the importance of hetereocyclic chemistry in drug discovery. Many drugs containing saturated heterocycles, heterocycles with more than two heteroatoms, and non-heterocycles. In the ensuing chapters, the most popular types of heterocycles in drug discovery are reviewed for their physical and chemical properties, their constructions in the context of medicinal chemistry, and their potential liabilities as drugs when applicable.

Other bioactive pyrroles shown as follows include an antipsychotic agent, a sodium-independent dopamine receptor antagonist, and a DNA cross-linking agent. Me o N' H M

NaOEt, EtOH, then ArH Ar1 C0 2 f-Bu H,C O CH 3 f-Bu0 2 C O O VCH, C0 2 Et Br Ar Ar 2 -NH 2 EtOH, HOAc Ar \ ^X. CH 3 C0 2 Et f-Bu0 2 C When Paal and Knorr discovered the pyrrole synthesis more than a century ago, they had no idea that the reaction bearing their names would have contributed greatly to the manufacture of atorvastatin (Lipitor). Indeed, synthesis of Lipitor is probably the tour deforce for the Paal-Knorr pyrrole synthesis. After more than one year's exploration, the carefully controlled conditions were worked out to prepare penta-substituted pyrrole in 43% yield.

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