By Richard F. Lockey, Dennis K. Ledford

Modernized and up-to-date, Allergens and Allergen Immunotherapy, Fourth Edition discusses all significant components of allergens and immunotherapies:

  • pollens
  • animal/insect
  • fungi
  • food
  • the manufacture and standardization of allergen vaccines
  • the management of vaccines
  • the avoidance and remedy of inauspicious effects

Compiling the study of an influential crew of investigators and scientists, Allergens and Allergen Immunotherapy is stuffed with speedy reference charts, tables and indexes. Allergists, immunologists, and otolaryngologists will locate this new streamlined fourth variation an outstanding useful reference for on-the-go analysis, therapy, and administration of allergies.

NEW TO THE FOURTH EDITION:

  • new specialise in the main appropriate info concerning allergens and immunotherapy
  • new concise chapters for simpler use as an everyday reference
  • the new innovative approach to sublingual swallow immunotherapy is totally discussed
  • describes inhaled, ingested, and injected allergens
  • allergen vaccines from formula to fabricate to administration
  • details the avoidance and therapy for hostile effects
  • covers allergen vaccines from formula to fabricate to administration

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Additional info for Allergens and allergen immunotherapy

Sample text

This concept was confirmed in 1926 by Levine and Coca (71) and Jadassohn (72), both of whom found clinical improvement and allergen activity to be independent of effect, if any, on skinsensitizing (reaginic) antibody. Levine and Coca’s study also demonstrated that a rapid (twoto fourfold) increase in serum reaginic antibody sometimes followed allergen injections. This finding helped to explain some paradoxical observations in treatment programs that had been designed to lessen specific hypersensitivities.

When the allergenic character of pharmaceutical and biological products derived from plant and animal sources became increasingly evident, attempts were made to desensitize reactive patients who otherwise would be deprived of essential specific therapy. An early problem was treatment of the horse-sensitive patient with horse antidiphtheria or antitetanus antiserum (160). The cautious injections of horse dander vaccine offered some measure of protection after long-term treatment (161). However, the potential for anaphylaxis resulting from the large volumes of therapeutic antisera required was too great.

Lancet 1908; 2(1):1589; (2):1689. 82. Farrington PM. Hay fever. Memphis Med J 1912; 32:381. 83. Morrey CB. Vaccination with mixed cultures from the nose in hay fever. J Am Med Assoc 1913; 61:1806. 84. Goodale JL. Preliminary notes on skin reactions excited by various bacterial proteins in certain vasomotor disturbances of the upper air passages. Boston Med Surg J 1916; 174:223. 85. Walker IC. Studies on the sensitization of patients with bronchial asthma to bacterial proteins as demonstrated by the skin reaction and the methods employed in the preparation of those proteins.

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