By Hugo O. Villar (Eds.)

The second one quantity in a sequence which goals to target advances in computational biology. This quantity discusses such issues as: statistical research of protein sequences; growth in large-scale series research; and the structure of loops in proteins

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For smaller laterally mobile proteins, the overlap in compositional profiles from 54 MOURITSEN, SPEROTTO, RISBO, ZHANG, and ZUCKERMANN adjacent proteins results in an effective lipid-mediated, protein-protein interaction which can give rise to an attractive force and hence protein aggregation. The mattress model for lipid-protein interactions, Eq. (6), has recently been used (Sperotto and Mouritsen, 1994) in conjunction with the model for binary mixtures of phospholipids with different acyl-chain lengths, Eqs.

Eq. (17). 36 Computation of Lipid-Protein Interactions 37 impossible to distinguish between a weak first-order transition and a pseudotransition dominated by very strong fluctuations. The numerical work presented here supports the hypothesis that lipid bilayers exhibit pseudocritical behavior and are close to a critical point (Biltonen, 1990; Mouritsen, 1991). B. Two-Component Lipid Bilayers The possible absence of a phase transition in one-component lipid bilayers poses some intriguing problems as to the existence of phase equilibria in lipid bilayers incorporated with other species, such as other lipids, cholesterol, or proteins.

1) (Mouritsen and Bloom, 1993) between the lipid-bilayer and the hydrophobic region of the protein. This concept has enjoyed considerable success in predicting phase diagrams for lipid bilayers reconstituted with specific proteins. Here we place special emphasis on this mechanism and we shall describe some of the results which have been obtained from computer-simulation calculations on the molecular interaction model known as the mattress model (Mouritsen and Bloom, 1984) which is based on this mechanism.

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