By Michael Robertson

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Low baseline white cell counts have not been associated with agranulocytosis whilst on clozapine treatment and African American’s do not appear to be at higher risk for agranylocytosis47. 43. Meltzer HY. Suicide and schizophrenia; clozapine and the InterSept study. Journal Clinical Psych. 1999;60(Suppl 12):47-50. 44. Gerson SL, Meltzer H. Mechanisms of clozapine-induced agranulocytosis. Drug Saf. 1992;7(Suppl 1):17-25. 45. Gerson SL, Arce C, Meltzer HY N-desmethylclozapine: a clozapine metabolite that suppresses haemopoiesis.

Individuals with BEN have a similar haematological response to infections as do those without BEN and do not show an increased incidence of infections45. Low baseline white cell counts have not been associated with agranulocytosis whilst on clozapine treatment and African American’s do not appear to be at higher risk for agranylocytosis47. 43. Meltzer HY. Suicide and schizophrenia; clozapine and the InterSept study. Journal Clinical Psych. 1999;60(Suppl 12):47-50. 44. Gerson SL, Meltzer H. Mechanisms of clozapine-induced agranulocytosis.

Williams K, Oke S. Lithium in Pregnancy. Psychiatric Bulletin. 2000);24:229-231. 63. Wogelius P, Nørgaard M, Munk EM, Mortensen PB, Lipworth L, Sørensen HT. Maternal use of selective serotonin reuptake inhibitors and risk of adverse pregnancy outcome (Abstract). Pharmacoepidem Drug Safety. 2005;14:S72-S73. 64. asp. 65. org HET I AC U T E PS Y C H IATRI C M A N A G E M E N T 41 Effects of untreated psychiatric disorder in pregnancy Any treatment decision must be weighed against the deleterious impact of untreated or suboptimally treated psychiatric disorder.

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